Colorectal carcinoma (CRC) is the third most common cancer and the fourth deadliest.Despite recent advances in screening methods and preoperative BUCKWHEAT HONEY imaging techniques, the threat of colorectal cancer remains at an all-time high.Moreover, even after curative treatment, disease recurrence occurs in up to 40% of all cases.However, half o
Examining heterogeneity of stromal cells in tumor microenvironment based on pan-cancer single-cell RNA sequencing data
Tumor tissues contain both tumor and non-tumor cells, which include infiltrated immune cells and stromal cells, collectively called the tumor microenvironment (TME).Single-cell RNA sequencing (scRNAseq) enables Graduation Cap Topper the examination of heterogeneity of tumor cells and TME.In this review, we examined scRNAseq datasets for multiple ca
Capsule Endoscope Aspiration after Repeated Attempts for Ingesting a Patency Capsule
Capsule endoscope aspiration into the respiratory tract is a rare complication of capsule endoscopy.Despite the potential seriousness of this complication, no accepted methods exist to accurately predict and therefore prevent it.We describe the case of an 85-year-old male who presented for evaluation of iron deficiency anemia.He complained of dysph
Discovery of lipid binding sites in a ligand-gated ion channel by integrating simulations and cryo-EM
Ligand-gated ion channels transduce electrochemical signals in neurons and other excitable cells.Aside from canonical ligands, phospholipids are thought to bind specifically to the transmembrane domain of several ion channels.However, structural details of such lipid contacts remain elusive, partly due to limited resolution of these regions in expe